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Document 0098
DOCN M9490098
TI Retroviruses and cutaneous T-cell lymphoma.
DT 9411
AU Lessin SR; Vowels BR; Rook AH; Department of Dermatology, University of
Pennsylvania,; Philadelphia.
SO Dermatol Clin. 1994 Apr;12(2):243-53. Unique Identifier : AIDSLINE
MED/94320347
AB Since the discovery of the first human retrovirus, HTLV-I, and its
etiologic role in ATL, the search for a retrovirus and its role in the
development and progression of CTCL has been vigorously pursued and
debated. Current studies in CTCL have evaluated serum antibodies to
retroviral proteins, electron microscopy to identify viruslike
particles, and Southern blot analysis and PCR amplification to detect
proviral DNA sequences. There have been inconsistent findings within and
between a variety of studies, emphasizing the need for critical
evaluation of experimental methods and their potential shortcomings.
Several interesting observations have included (1) serologic evidence of
HTLV-I infection in a small subset of CTCL patients, (2) cloning of a
deleted HTLV-I proviral genome from a B-cell line established from the
peripheral blood of a CTCL patient, (3) detection of retrovirus in
Langerhans cells and B cells, and (4) molecular evidence for the
presence of an HTLV-I-like retrovirus. By viewing CTCL as a model of
tumor progression, mechanisms by which retroviruses play a role in the
development and progression of CTCL are facilitated. Future studies will
need to correlate the detection of proviral sequences and the nature of
a retroviral infection with specific cell types and stage of disease and
determine if these findings demonstrate a causal role in CTCL or a
secondary phenomenon due to CTCL-associated immunosuppression. It is
likely that new data will be reported between the writing of this
article and the time of publication; however, the currently available
data reviewed in this article do not provide conclusive evidence that
retroviruses play a primary etiologic role in CTCL.
DE DNA, Viral/ANALYSIS Human Leukemia-Lymphoma, T-Cell, Acute,
HTLV-I-Associated/MICROBIOLOGY/ PATHOLOGY Lymphoma, T-Cell,
Cutaneous/*MICROBIOLOGY/PATHOLOGY Polymerase Chain Reaction
Retroviridae/*PATHOGENICITY *Retroviridae Infections Skin
Neoplasms/*MICROBIOLOGY/PATHOLOGY Support, U.S. Gov't, Non-P.H.S.
Support, U.S. Gov't, P.H.S. Tumor Cells, Cultured *Tumor Virus
Infections JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).